close up of human eye and science illustration

ISB was created in 2000 as the first-ever institute dedicated to systems biology.

We are a collaborative and cross-disciplinary nonprofit biomedical research organization based in Seattle. We focus on some of the most pressing issues in human health, including brain health, cancer and aging, as well as many chronic and infectious diseases. Our science is translational, and we champion sound scientific research that results in real-world clinical impacts. ISB is an affiliate of Providence, one of the nation’s largest not-for-profit health care systems.

ISB serves as the ultimate environment where scientific collaboration stretches across disciplines and across academic and industrial organizations, where our researchers have the intellectual freedom to challenge the status quo, and where grand visions for breakthroughs in human health inspire a collective drive to achieve the seemingly impossible.